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Headache has been reported in up to 3-16 1, 23, 41, 75 and dizziness, nervousness, insomnia, somnolence, malaise, and fatigue have been reported in up to 4 of patients receiving cefixime.

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Some people allergic to penicillin may also be allergic to cephalosporins such as cefixime.

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We report 4 urogenital neisseria gonorrhoeae isolates recovered from 3 patients that demonstrated resistance to penicillin, tetracycline, and ciprofloxacin and reduced susceptibility to cefixime.

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Cefixime may cause live bacterial vaccines such as typhoid vaccine to not work as well.

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It has been suggested that cefixime be reserved for the treatment of utis caused by multidrug-resistant gram-negative bacteria e.