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Adverse effects are possible when taking coreg.

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The concomitant administration of amiodarone or other cyp2c9 inhibitors such as fluconazole with coreg may enhance the -blocking activity resulting in further slowing of the heart rate or cardiac conduction.

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Coreg may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents.

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Of the 1,156 subjects randomized to coreg in a long term, placebo controlled trial in severe heart failure, 47 547 were aged 65 years or older, and 15 174 were aged 75 years or older.

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There were no reports of bradycardia in the clinical trial of coreg cr in hypertension.