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Metformin moderate sulfonamides may induce hypoglycemia in some patients by increasing the secretion of insulin from the pancreas.

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In prostate cancer, the metformin active surveillance trial nct01864096 , an ongoing randomised phase iii trial of metformin versus placebo given before primary therapy is assessing time to progression in men with low-risk prostate cancer.

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In controlled clinical trials, pioglitazone had an additive effect on glycemic control when used in combination with a sulfonylurea, metformin, or insulin see clinical studies .

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Alogliptin metformin is a member of the antidiabetic combinations drug class and is commonly used for diabetes – type 2.

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There was no evidence of a mutagenic potential of glycomet gp metformin hydrochloride in the following in vitro tests ames test s.